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South London Healthcare Trust Announces Partnership With NHS Institute For Innovation And Improvement In Its Drive For Clinical Excellence
South London Healthcare NHS Trust (SLHT) is delighted to announce a new partnership with the NHS Institute for Innovation and Improvement as part of the trust"s drive for

Tighter Surveillance Of Swine Flu In Pigs Needed Worldwide Says CDC
The US Centers for Disease Control and Prevention (CDC) said that there is a "global need for more systemic surveillance of influenza viruses
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Appetite-Stimulating Hormone Is First Potential Medical Treatment For Frailty In Older Women
Older women suffering from clinical frailty stand to benefit from the first potential medical treatment for the condition, according to a study presented today by Penn Medicine researchers at ENDO, The Endocrine Society"s 91st Annual Meeting. Ghrelin, a hormone that stimulates appetite, was administered to older women diagnosed with frailty, a common geriatric syndrome characterized by unintentional weight loss, weakness, exhaustion and low levels of anabolic hormones which increases risk of falls, hospitalizations, disability, and death. Those who received ghrelin infusions consumed 51 percent more calories than the placebo group, with an increase in carbohydrate and protein intake, not fat. Their growth hormone levels were also higher throughout the ghrelin infusion.
Nutrition

Blood-Borne Molecule Helps Regulate Blood-Vessel Integrity

Although maintaining the integrity of blood vessel walls is essential for life, well-controlled temporary leakage of blood contents through the walls of blood vessels into the tissues is a hallmark of inflammation. Although the molecule S1P is known to act on the cells that line blood vessels (endothelial cells) to regulate the permeability of blood vessel walls, the in vivo of SIP in this process remains unknown, and whether it has a role in inflammation has not been determined. In a new study, Shaun Coughlin and colleagues, at UCSF, San Francisco, have shed light on these issues, revealing that mice that lack S1P selectively in plasma (the liquid component of blood) have increased leakage from the blood vessels in response to a variety of stimuli, including inflammatory ones. As the leakage was reversed by treatment with either S1P-containing red blood cells or an agonist for the protein to which SIP binds, the authors conclude that S1P in the blood regulates blood-vessel integrity and prevents potentially lethal decreases in blood volume after exposure to leak-inducing stimuli. TITLE: Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice AUTHOR: Shaun R. Coughlin University of California, San Francisco, San Francisco, USA. View the PDF of this article at: https://www.the-jci.org/article.php?id=38575 Karen Honey Journal of Clinical Investigation JCI online early table of contents: June 15, 2009


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