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Popular Articles

Changes In Stair Design Could Help Fight Obesity
Some simple changes in the design and location of staircases could help to make buildings more "physical activity friendly" and contribute to the fight against obesity, according to an article in the June Southern Medical Journal, official journal of the Southern Medical Association. The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health, a leading provider of information and business intelligence for students, professionals, and institutions in medicine, nursing, allied health, pharmacy and the pharmaceutical industry.

Ceregene Presents Additional Clinical Data From Phase 2 Trial Of CERE-120 For Parkinson's Disease
Ceregene, Inc. reported additional clinical data from a double-blind, controlled Phase 2 trial of CERE-120 in 58 patients with advanced Parkinson"s disease. CERE-120 uses AAV-based gene therapy to deliver the neurotrophic factor, neurturin, to Parkinson"s disease patients in order to restore the function and protect degenerating nigrostriatal neurons. The company previously announced that the Phase 2 trial did not meet its primary endpoint of improvement in the Unified Parkinson"s Disease Rating Scale (UPDRS) motor off score at 12 months of follow-up, although several secondary endpoints suggested a modest clinical benefit.
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Daily Sex Helps To Reduce Sperm DNA Damage And Improve Fertility
Daily sex (or ejaculating daily) for seven days improves men"s sperm quality by reducing the amount of DNA damage, according to an Australian study presented to the 25th annual meeting of the European Society of Human Reproduction and Embryology in Amsterdam.
Mental Health

Carbon Monoxide Prevents Clotting

Researchers led by Drs. James F. George and Anupam Agarwal at the University of Alabama at Birmingham have found that carbon monoxide (CO) can protect against arterial clotting. They report their data in the July 2009 issue of the American Journal of Pathology. Carbon monoxide poisoning is extremely toxic; exposure prevents oxygen delivery to body tissues and is often fatal. However, inflamed or injured tissues upregulate heme oxygenase-1 (HO-1), a protein that both protects cells and produces CO, suggesting that low levels of CO may have protective effects. To determine if HO-1 and CO can protect against arterial clotting, Chen et al examined clotting mechanisms in mice that received arterial transplants. Absence of HO-1 in these mice resulted in significant mortality due to arterial clotting; however, treatment with a CO-releasing molecule both decreased clotting and improved survival. Drs. George, Agarwal, and colleagues conclude that HO-1/CO plays an "important role ò€¦[in] protection against vascular arterial thrombosis in murine aortic allotransplantation." Chen B, Guo L, Fan C, Bolisetty S, Joseph R, Wright MM, Agarwal A, George JF: Carbon Monoxide Rescues Heme Oxygenase-1-deficient Mice from Arterial Thrombosis in Allogeneic Aortic Transplantation. Am J Pathol 2009, 174: 2832-2839 Angela Colmone American Journal of Pathology


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