Sexual HealthImmunoVaccine Technologies Partners With FIT Biotech To Advance A Therapeutic HIV Vaccine
ImmunoVaccine Technologies Inc. (IVT), a Canadian vaccine development
company, announced a research partnership with FIT Biotech, a Finland-based
, clinical stage company that develops DNA vaccines. This research will
formulate FIT Biotech"s GTU(R) MultiHIV DNA plasmid with IVT"s DepoVax(TM)
vaccine delivery system to advance a therapeutic HIV vaccine.
"DepoVax(TM) will act as a vector to deliver FIT Biotech"s GTU(R)
MultiHIV DNA vaccine and our goal is to develop a more sophisticated and
efficient HIV vaccine candidate," commented Dr. Marc Mansour, Vice
President R&D at IVT.
The development of an HIV vaccine is complicated by the ability of the
virus to mutate rapidly. FIT Biotech has addressed this challenge by
designing a synthetic DNA plasmid, known as GTU(R) MultiHIV that covers the
antigenic variability within HIV strains. GTU(R) MultiHIV and is comprised
of the multi-epitope/multivalent HIV antigens. As FIT Biotech"s lead
vaccine candidate, GTU(R) MultiHIV has the potential to trigger an immune
response that slows the progression of HIV in infected individuals.
IVT"s pre-clinical research demonstrates that DepoVax(TM) effectively
delivers DNA plasmids into draining lymph nodes with as little as one dose.
The DepoVax(TM) platform uses liposomes to encapsulate a target antigen,
like GTU(R) MultiHIV, and adjuvant. DepoVax(TM) also relies on a
hydrophobic carrier to create a depot effect that significantly enhances
vaccine induced cell-mediated and humoral immunity.
This pre-clinical research partnership will combine the complementary
technologies of DepoVax(TM) and GTU(R) MultiHIV. Both IVT and FIT Biotech
will examine the novel vaccine"s capabilities of inducing cell-mediated and
humoral immunity against HIV virus.
"By testing DepoVax(TM) in combination with GTU(R) MultiHIV plasmid,
we are working towards developing a superior vaccine candidate for
therapeutic use against HIV and AIDS," said Kalevi Reijonen, President and
CEO at FIT Biotech.
The WHO reports that 33 million people are living with HIV and the
epidemic is rapidly expanding with 2.7 million people newly infected in
2007. Nearly all of them will develop AIDS-related complications, creating
an urgent need for effective HIV therapeutic vaccines. Therapeutic
vaccination offers the most hope for HIV infected individuals because it
maintains a low viral load and has the potential to modify the course of
the infection and its progression towards the AIDS disease.
ImmunoVaccine Technologies Inc.