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Strength Training And Aerobic Exercise Both Lower Cardiovascular Risks, Reduce Pain
Different types of work site exercise programs have multiple benefits, including reduced neck and shoulder pain for employees who do all-around exercise and lowered heart disease and stroke risk factors for those who do strength training, reports a study in the July Journal of Occupational and Environmental Medicine, official publication of the American College of Occupational and Environmental Medicine (ACOEM).

Global Commitment Announced In Fight Against Leading Killer Of Children
A new strategy in the fight against pneumonia, the world"s greatest killer of children, was announced in Lecce, Italy. Global health partners gathered to sign an innovative new financing agreement called the Advance Market Commitment (AMC), designed to accelerate access to life-saving new vaccines and medicines in developing countries.
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Relationship Between Bone Density And Erosion In Arthritis
Rheumatoid arthritis (RA), the most common form of inflammatory arthritis, affects almost three percent of people over age 65. RA patients experience pain, functional limitations and two forms of disabling bone disease: focal erosions and osteoporosis. After five years of disease, up to 50 percent of RA patients show evidence of focal erosions and RA doubles the risk of osteoporosis and fractures. A new study examined the relationship between these two RA-related processes, in the hopes of providing insight into the underlying pathophysiology of RA-related bone disease. The study was published in the June issue of Arthritis & Rheumatism.
Cardiovascular

Maternal Immunity Not All Good For A Fetus

As a fetus does not mount an immune response to maternal proteins that cross the placenta, it has been assumed that a fetus would not reject non-genetically matched blood cells (specifically allogeneic blood cells) if they were transplanted while the fetus was in utero. The hope is that this procedure, which is known as IUHCT, could provide a viable approach for treating congenital blood disorders. However, studies using a mouse model of IUHCT indicate that most fetal recipients of allogeneic blood cells lose their transplanted cells 3-5 weeks after transplantation. Alan Flake and colleagues, at Children"s Hospital of Philadelphia, have now identified an immune mechanism responsible for graft failure in this model of IUHCT. Surprisingly, although fetal immune cells eliminated the transplanted allogeneic blood cells, they were triggered to do so by immune molecules known as alloantibodies that they obtained from their mother"s breast milk. The maternal alloantibodies were produced in response to IUHCT and so the authors conclude that in the absence of either a maternal immune response or transmission of the maternal alloantibodies to the fetus, transplanted blood cells should not be rejected, leaving open the door for IUHCT as a potential clinical strategy. TITLE: Maternal alloantibodies induce a postnatal immune response that limits engraftment following in utero hematopoietic cell transplantation in mice AUTHOR: Alan W. Flake Children"s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. PDF of this article. Karen Honey Journal of Clinical Investigation


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