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Popular Articles

Molecule Helps Breast Cancer Cells To Survive In The Bone Marrow
Patients who survive an initial diagnosis of breast cancer often succumb to the disease years later when the cancer shows up in a different part of the body. Now, scientists have identified key signals that support the long term survival of breast cancer cells after they have spread to the bone marrow. The research, published by Cell Press in the July issue of the journal Cancer Cell, may lead to development of treatment strategies that decrease the likelihood of breast cancer recurrence in the bone and other organs.

Alkermes Initiates Two New Clinical Trials Of ALKS 33
Alkermes, Inc. (NASDAQ: ALKS) announced the initiation of two new clinical trials of ALKS 33, an oral opioid modulator for the potential treatment of addiction and other nervous system disorders. Study ALK33-004 is a phase 1 clinical trial designed to examine the ability of ALKS 33 to block the effects of an opioid following a single oral dose of ALKS 33 in healthy, non-dependent, opioid-experienced subjects. Study ALK33-003 is a phase 1 clinical trial designed to evaluate the pharmacokinetics, safety and tolerability of multiple doses of ALKS 33 in healthy volunteers.
News of the day
Head Of Urologic Oncology At The Cancer Institute Of New Jersey Marks 500th Robotic Prostatectomy
Marking a unique milestone in prostate cancer surgery, the director of urologic oncology at The Cancer Institute of New Jersey (CINJ) has completed his 500th robotic prostatectomy at Robert Wood Johnson University Hospital (RWJUH), the Flagship Hospital of CINJ, which is a Center of Excellence of UMDNJ-Robert Wood Johnson Medical School.
Diagnostics

Using Ultrasound To Detect Early Signs Of Osteoarthritis

Researchers at The University of Nottingham are hoping to find out if inflammation of the knee could be an early sign of osteoarthritis - a condition which leads to pain, stiffness, swelling and disability. Up to six million people in the UK suffer from osteoarthritis in the knee. Now 200 patients, over the age of 55, from GP practices across Nottingham are to take part in a study led by research physiotherapist Michelle Hall in the School of Nursing, Midwifery and Physiotherapy. Mrs Hall, who is a lecturer in the Division of Physiotherapy Education, said: "It has been shown that people who have inflammation may develop more severe and progressive osteoarthritis and experience greater pain and disability. The ability to detect the presence of inflammation using Ultrasound could therefore be important in terms of prognosis and selection of certain treatments." With a three-year training fellowship from the Arthritis Research Campaign of ÷£192,000 Mrs Hall will use new ultrasound techniques to identify if this common condition, in people over 55, can be linked to osteoarthritis. At the moment osteoarthritis can only be identified by x-ray, which is limited to revealing changes to bones and degeneration of cartilage. It does not show up any changes or inflammation to the surrounding soft tissue or joint lining. This inflammation may also contribute to pain and stiffness and could, in fact, be a precursor to osteoarthritis. Osteoarthritis is known as a "wear and tear" condition in which cartilage wears away, leaving bones rubbing together. Recently scientists have shown that inflammation in the joint lining may also play a role in its development. The team from The University of Nottingham"s physiotherapy education and academic rheumatology departments aim to find out if people with knee pain and/or knee osteoarthritis also have inflammation in their knees. Patients will attend the Clinical Sciences Building at the University for the ultrasound scans which will repeated three months later or if participants report a change in their knee pain, to chart the progress of the inflammation to see whether this correlates with x-ray changes or with increases in pain. A control group of healthy volunteers will also undergo ultrasound on their knees as a comparison group. Michelle Hall University of Nottingham


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