Medical Devices
A possible government rethink into the "flawed and expensive" private financing of NHS hospitals has been welcomed by Unite, the largest union in the country.
The Chief Medical Officer, Sir Liam Donaldson and the All Party Parliamentary Thrombosis Group are today holding a leadership summit on venous thromboembolism (VTE) in the NHS. Health Minister, Ann Keen, the All Party Chair, John Smith MP, and NHS Medical Director, Sir Bruce Keogh are among the speakers at event to raise awareness of the Department of Health"s prevention strategy for VTE. NHS senior managers will learn of the comprehensive and important drive to save lives from this important cause of avoidable death.
According to new research* carried out by Lloydspharmacy, the UK"s leading community pharmacy chain, around 2.1million British holidaymakers and travellers are ignoring the need to protect themselves against malaria.
Vision loss costs Canadian society a staggering $15.8 billlion per year - significantly higher than previously estimated, according to new research study released on June 23, 2009, by CNIB and the Canadian Ophthalmological Society (COS). The study"s proponents say these costs, which are expected to increase dramatically in the years ahead, underscore the urgent need for Canada to develop a comprehensive national vision health plan.
U.S. Marshals, at the request of the Food and Drug Administration, today seized drug products manufactured by Caraco Pharmaceutical Laboratories Ltd. (Caraco), at the company"s Michigan facilities in Detroit, Farmington Hills, and Wixom. The seizure also includes ingredients held at these same facilities. "The FDA is committed to taking enforcement action against firms that do not manufacture drugs in accordance with our good manufacturing practice requirements," said Janet Woodcock, M.D., director of the FDA"s Center for Drug Evaluation and Research. "Compliance with these standards prevents harm to the public."
California Gov. Arnold Schwarzenegger (R) outlined two budget proposals to address the state"s budget problems, and both plans would affect health care, the Los Angeles Times reports. The first proposal addresses the situation if California voters approve a set of special ballot measures intended to provide funds for fiscal year 2009-2010. The state would still face a $15.4 billion budget deficit even if voters approve the measures, and the second proposal addresses that scenario (Rothfeld, Los Angeles Times, 5/15). The governor proposed $750 million in cuts to Medi-Cal, the state"s Medicaid program, that would reduce eligibility and provider rates. The state would need to seek a federal waiver to implement the cuts. The governor also proposed eliminating eligibility for non-emergency Medi-Cal benefits for documented immigrants (Colliver, San Francisco Chronicle, 5/15). Spending for centers that provide services to people with developmental disabilities would be cut by $234 million (Zapler, San Jose Mercury News, 5/14).If voters do not approve three ballot measures, Schwarzenegger outlined $800 million in additional cuts to health and human services programs, including a proposal to eliminate Healthy Families coverage for about 225,000 children. Healthy Families is California"s CHIP (Yi et al., San Francisco Chronicle, 5/15).
The Senate Commerce Committee has found that a flawed payment database produced by a UnitedHealth subsidiary and distributed to other major insurance companies has led insurers to underpay millions of out-of-network claims, forcing patients to make up the difference of health care providers" fees, the Wall Street Journal reports. Aetna, Cigna, WellPoint, and other large insurers used the data to calculate their "reasonable and customary" charges. They also provided UnitedHealth"s subsidiary, Ingenix, with historic data about their payments, which became the foundation of ongoing versions of the flawed payment models.
Staying ahead of the upcoming drive to sell electronic health records to hospitals and physicians may be difficult for smaller vendors, Pharmawire/Financial Times reports. General Electric announced a program last week to provide health care organizations with financing options to purchase health technology through its financial services arm even as it sells electronic records through its health care wing. Other large vendors like Cerner and McKesson will be able to keep up, but smaller producers will be left behind, industry experts said.
Polk County, Fla., health officials have made educating the black community a top priority in addressing HIV/AIDS in the state, where blacks are disproportionately affected by the virus, the Lakeland Ledger reports. The Polk County Health Department has expanded its community outreach and testing efforts to different types of settings such as beauty salons, community centers and churches. County outreach workers hope that offering education and screening in such settings will encourage residents to get informed and tested for HIV (Williams Adams [1], Lakeland Ledger, 6/24). In addition, the Ledger examined the complex issues the black community faces with regard to HIV/AIDS and the barriers that need be addressed to reduce the impact of HIV/AIDS on minorities (Williams Adams, Lakeland Ledger, 6/25). The Ledger also profiled Bonnie Munson, a local resident who performs volunteer outreach efforts in her community, including distributing condoms and informational material to other residents (Williams Adams [2], Lakeland Ledger, 6/24).
Taiwan
In an article published in the June 25th edition of the journal Neuron, researchers at the Hotchkiss Brain Institute, University of Calgary, have found that synaptic plasticity, long implicated as a device for "change" in the brain, may also be essential for stability.
As a woman gets older, physical problems are less likely to influence whether she is sexually active than her partner"s health or interest in sex, according to a new study by researchers at the University of California, San Francisco and Kaiser Permanente.
UCB announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMEA) has issued a positive opinion recommending that the European Commission grants a marketing authorisation for Cimzia® (certolizumab pegol), in combination with methotrexate (MTX), for the treatment of moderate to severe active rheumatoid arthritis in adult patients when the response to disease-modifying anti-rheumatic drugs (DMARDs) including MTX, has been inadequate. In these patients, Cimzia® can be given as monotherapy in case of intolerance to MTX or when continued treatment with MTX is inappropriate. Cimzia® has been shown to reduce the rate of progression of joint damage as measured by X-ray and to improve physical function, when given in combination with MTX.
Biotechnology Industry Organization (BIO) President and CEO Jim Greenwood issued the following statement regarding the letter sent yesterday from the Obama Administration to House Energy and Commerce Committee Chairman Henry Waxman regarding biosimilars:
Researchers at the Yerkes National Primate Research Center, Emory University, have demonstrated for the first time rhesus monkeys and humans share a specific perceptual mechanism, configural perception, for discriminating among the numerous faces they encounter daily. The study, reported in the June 25 online issue of Current Biology, provides insight into the evolution of the critical human social skill of facial recognition, which enables us to form relationships and interact appropriately with others.
Agreeing with the broad goals and most of the underlying policies contained in a comprehensive draft bill on health care reform legislation, the American College of Physicians (ACP) has praised the House "tri-committee." Made up of the House Ways and Means, Energy and Commerce, and Education and Labor Committees, the "tri-committee" unveiled its proposed legislation on June 19.
Does quantum mechanics show a connection between the human mind and the cosmos? Are our brains tuned into a "cosmic consciousness" that pervades the universe enabling us to make our own reality? Do quantum mechanics and chaos theory provide a place for God to act in the world without violating natural laws?
German pain expert company GrÃønenthal GmbH announces that the new centrally acting analgesic tapentadol is now available in the United States. The drug is indicated for the relief of moderate to severe acute pain in patients 18 years of age and older. Approval was given by the US Food and Drug Administration (FDA) in November 2008 for tapentadol (NUCYNTATM) tablets. With the cooperation of GrÃønenthal and its marketing partner Ortho-McNeil-Janssen Pharmaceuticals, Inc., the medication can now be prescribed by physicians and other appropriate health care professionals in the United States.
Any cancer - a growth, lump, tumor - of the colon and the rectum is a type of colorectal cancer. Colorectal cancer is also known as bowel cancer. The UK National Health Service says colorectal cancer is the most common cancer globally today. However, the World Health Organization says it is the second most common cancer, after lung cancer. A US study found that incidence rates among adults younger than age 50 years are increasing.
Pope Benedict XVI has agreed to meet with President Obama at the Vatican on July 10, according to White House spokesperson Robert Gibbs, the AP/Boston Globe reports. The Rev. Federico Lombardi, a Vatican spokesperson, on Wednesday said that the pope will hold an afternoon meeting with the president and first lady Michelle Obama after the conclusion of the Group of Eight industrialized nations summit meeting, a break with a Vatican tradition of holding midday meetings. The AP/Globe reports that the Vatican "clearly sought to accommodate" the president"s schedule, an indication that Benedict is interested in meeting with Obama despite his support for abortion rights and embryonic stem cell research.Some U.S. bishops have publicly attacked Obama"s support of abortion rights and embryonic stem cell research, which has fueled anticipation of a meeting between the president and the pope. Most recently, dozens of bishops denounced the University of Notre Dame"s decision to invite Obama to deliver its commencement address and receive an honorary degree. However, L"Osservatore Romano, the Vatican"s daily newspaper, said that Obama"s speech showed that he is looking for common ground on issues related to abortion. Obama also received a positive review from the newspaper after his first 100 days in office. An editorial in the paper said that Obama had not confirmed the "radical" direction on ethical questions he had discussed as a candidate (Simpson, AP/Boston Globe, 6/24).
The Wall Street Journal reports that drug companies are increasingly using medical science liaisons: "Pharmaceutical companies are barred by the Food and Drug Administration from promoting unapproved drug uses, called off-label use, but they are using employees called "medical science liaisons," who are often physicians and pharmacists, as a legal way to discuss those uses. Medical science liaisons, who are considered medical rather than sales staff, have greater freedom than salespeople as they visit doctors offices to discuss the science behind a medicine, including unapproved uses." It notes: "The FDA requires traditional sales reps to refer information requests to their employers" medical or scientific staff, MSLs are usually on those staffs."
Mexican President Felipe Calderon and Chilean President Michelle Bachelet on Thursday emphasized the importance of developing countries having access to a vaccine that offers protection against the H1N1 (swine flu), "that has killed over 200 people and infected tens of thousands worldwide," AFP/MSN Philippine News reports.
Many people who test positive for HIV are diagnosed late in the course of their infection when treatment might be less effective, according to a report published Thursday in CDC"s Morbidity and Mortality Weekly Report, Reuters Health reports. The report looked at data on people who were diagnosed with HIV from 1996 to 2005 and found that 45 percent had developed AIDS within three years of their initial HIV diagnosis, 38.3 percent within one year and an additional 6.7 percent within the next two years (Reuters Health 6/25). R. Luke Shouse of CDC"s Division of HIV/AIDS Prevention in the National Center for HIV/AIDS, Viral Hepatitis, STD and TB Prevention, said, "This means that they may have unknowingly transmitted HIV. It also means that there is a time when they had HIV when they were not under appropriate medical care, so there are missed opportunities for prevention and care." A separate CDC report also published yesterday found that 22.3 percent of high school students who are sexually active and 12.9 percent of all students have been tested for HIV (Reinberg, HealthDay/KATC.com, 6/25).
The Kaiser Family Foundation, ahead of National HIV Testing Day on Saturday, has released new and updated informational res on HIV testing in the U.S., including a fact sheet that provides HIV testing statistics, policies and CDC recommendations. In addition, the Foundation released two survey briefs, which examine the public"s attitudes, experiences and knowledge related to HIV testing, one of which focuses on black residents. The briefs are based on the 2009 Survey of Americans on HIV/AIDS released this spring. Information regarding HIV testing by state also is available through statehealthfacts.org (Kaiser Family Foundation release, 6/24).
A clinical trial of masitinib, a drug in development for the treatment of rheumatoid arthritis, has shown it to be well tolerated and effective. Researchers writing in BioMed Central"s open access journal Arthritis Research and Therapy have shown that treatment with masitinib significantly reduced the severity of active arthritis.
While most fans are in awe of what their football heroes can do with a football, the of their remarkable skill remains strangely mysterious. Although being in excellent physical condition undoubtedly helps, few people actually believe that intense physical training alone can turn an average bloke into a Ronaldo. Now, scientists from the University of Queensland have decided to study what this "something else" might be. Dr. Robbie Wilson talked about the details of this study and the results that have been obtained so far in his talk at the Society of Experimental Biology Annual Meeting in Glasgow on Sunday 28th June 2009.
Hot or not? Men agree on the answer. Women don"t.
In one of the most field-intensive efforts to explore the connection between malaria and tropical deforestation, a team led by Jonathan Patz, a specialist in the link between environment and health at the Nelson Institute for Environmental Studies at the University of Wisconsin-Madison, has established a strong correlation between the extent of forest destruction and the incidence of the Amazon"s most dangerous malaria vector, the mosquito Anopheles darlingi.
The American Public Health Association (APHA) applauds the House for today passing a comprehensive climate change bill that includes important provisions to protect the health of the public.
Researchers in Berlin, Germany have ameliorated inflammation of the brain in mice caused by immune cells. A receptor they discovered on the surface of T cells in the central nervous system (CNS) plays the key role. The researchers showed that this bradykinin receptor 1 (B1) controls the infiltration of immune cells into the CNS. When they activated B1 in mice with encephalitis, they were able to slow down the crossing of the immune cells through the blood-brain-barrier into the CNS. As a result, the inflammation markedly decreased. The work by Dr. Ulf Schulze-Topphoff, Prof. Orhan Aktas, and Professor Frauke Zipp (Cecilie Vogt-Clinic, Charité - Universitätsmedizin Berlin, Max DelbrÃøck Center for Molecular Medicine (MDC) Berlin-Buch and NeuroCure Research Center) together with researchers in Canada and the USA may unveil a new target for the treatment of chronic inflammatory diseases such as multiple sclerosis (MS) (Nature Medicine, doi 10.1038/nm.1980)*.
When a patient is diagnosed with metastatic disease the primary site of the cancer is usually, but not always, evident. When the origin of the cancer is not identified it is described as a Cancer of Unknown Primary site, or CUP.
A series of articles in the July/August 2009 issue of The Journal of Midwifery & Women"s Health (JMWH) focuses on midwives" participation in the education of medical students and residents. This issue includes the results of a new national survey by Edie McConaughey, CNM, MS and Elisabeth Howard, CNM, PhD, which found that the number of midwives involved in medical education in the United States has tripled in the past 10 years. More recently, the growth of this model has accelerated secondary to the mandated decrease in resident work hours.
Diabetes patients who are hospitalized for non-critical illnesses, and develop hypoglycemia while hospitalized, are likely to remain hospitalized longer and face greater risk of mortality both during and after hospitalization, according to a study published in the July issue of Diabetes Care.
UCB announced that Neupro® (rotigotine transdermal patch) can now be prescribed to all patients with idiopathic Parkinson"s disease in Europe and is newly available for the symptomatic treatment of moderate to severe idiopathic Restless Legs Syndrome (RLS) in adults. This follows the decision of the European Commission to lift treatment restrictions on Neupro® in line with the recommendation of the European Medicines Agency (EMEA), issued on 29 May 2009.
The Centers for Disease Control and Prevention (CDC) today unveiled LEANWorks!, a Website designed to help businesses address obesity. LEAN stands for Leading Employees to Activity and Nutrition. The new Website was announced at a National Business Group on Health meeting in Washington, D.C.
Xencor, Inc., an antibody discovery and development company, will present data from its Phase 1 study of XmAb®2513, an anti-CD30 Fc engineered humanized monoclonal antibody for the treatment of patients with relapsed Hodgkin lymphoma and anaplastic large cell lymphoma, on June 1 in a poster session at the American Society of Clinical Oncology Annual Meeting being held at the Orange County Convention Center in Orlando, Florida.
Complications in early pregnancy or in previous pregnancies can predict the likelihood of further problems in current or subsequent pregnancies, according to research carried out by an international group of experts.
DOR BioPharma, Inc. (DOR or the Company) (OTC Bulletin Board: DORB), a late-stage biopharmaceutical company, announced that investigators at the Fred Hutchinson Cancer Research Center, Seattle, Washington, published a paper this morning in Bone Marrow Transplantation in which they demonstrate that DOR"s lead product orBec(R) (oral beclomethasone dipropionate or BDP) decreases non-infectious inflammation of the lung in acute gastrointestinal Graft-versus-Host disease (GI GVHD) patients who received allogeneic hematopoietic cell transplants (HCT). Non-infectious inflammation of the lung is a common and potentially fatal complication of HCT that decreases the exchange of oxygen and carbon dioxide between the lung and blood and, in its severe form, may present as interstitial pneumonitis. The full article, entitled "Influence of Oral Beclomethasone Dipropionate on Early Non-Infectious Pulmonary Outcomes after Allogeneic Hematopoietic Cell Transplantation.
AcelRx Pharmaceuticals, Inc. announced positive results from the second Phase 2 clinical study evaluating the safety and efficacy of its ARX-01 Sufentanil NanoTabs(TM) for the management of acute post-operative pain in patients requiring opioid analgesia during hospitalization. Compared to placebo, patients receiving ARX-01 Sufentanil NanoTabs for management of post-operative pain following major abdominal surgery reported statistically significant reductions in pain intensity over the 12-hour study period.
Sosei Group Corporation ("Sosei"; TSE Mothers Index: 4565) and Vectura Group plc ("Vectura"; LSE: VEC) announce the commencement of a Phase III clinical study by Novartis, with NVA237, a once-daily, long-acting muscarinic antagonist (LAMA) for the treatment of chronic obstructive pulmonary disease (COPD). NVA237 is a dry powder formulation for oral inhalation of glycopyrronium bromide, a LAMA with a rapid onset of activity. The study has now appeared on clinicaltrials.gov and will be recruiting in the next few weeks when the first patient first visit will trigger a $7.5 million milestone payment to both Sosei and Vectura.
Takeda Pharmaceutical Company Limited ("Takeda") announced that Takeda Global Research & Development Center, Inc., a wholly owned United States (U.S.) subsidiary received on June 26 (U.S. time) a complete response letter from the U.S. Food and Drug Administration (FDA) regarding the Company"s New Drug Application (NDA) for alogliptin, a selective dipeptidyl peptidase IV (DPP-4) inhibitor under investigation for the treatment of type 2 diabetes as an adjunct to diet and exercise. In recent months, the FDA and Takeda have been in discussions about conducting an additional cardiovascular study for alogliptin.
Researchers from the Peninsula Medical School, along with collaborators from research institutions across Europe and the United States, have for the first time identified two genes that are involved in determining when girls begin menstruation. The work will be published in Nature Genetics this weekend.
Pig heart valves used to replace defective aortic valves in human patients failed much earlier and more often than expected, says a report from cardiac surgeons at Washington University School of Medicine in St. Louis. This is the first report to demonstrate this potential problem, the researchers say.
Black gay men have less choice when it comes to sexual partners than other groups and, as a result, their sexual networks are closely knit. These tightly interconnected networks make the rapid spread of HIV more likely. In a study1) looking at social and sexual mixing between ethnic groups in men who have sex with men, H. Fisher Raymond and Willi McFarland, from the San Francisco Department of Public Health in the US, show that social barriers faced by Black gay men may have a serious impact on their health and well-being. Their findings are published in Springer"s journal AIDS and Behavior.
The high-intensity training undertaken by triathletes has a significant impact on the quality of their sperm, the 25th annual conference of the European Society of Human Reproduction and Embryology heard 29 June. Professor Diana Vaamonde, from the University of Cordoba Medical School, Cordoba, Spain, said that the triathletes who did the most cycling training had the worst sperm morphology.
Massachusetts-based Catholic hospital system Caritas Christi Health Care on Friday ended its joint venture with the Missouri-based health insurer Centene after Cardinal Sean O"Malley of the Archdiocese of Boston insisted that the relationship linked Catholic hospitals too closely to abortion providers, the AP/San Francisco Chronicle reports (AP/San Francisco Chronicle, 6/27). Under the joint venture, Caritas and Centene created a new company, CeltiCare, which would have insured thousands of low-income Massachusetts residents under Commonwealth Care, the state"s subsidized health care program. Financially troubled Caritas, which was founded by the Archdiocese of Boston, said it will continue to participate as a provider in Commonwealth Care but will no longer be a co-owner of the insurance venture with Centene. Caritas will provide care to patients covered by Centene, as it does for patients covered by other private insurers, but it will not provide any services that violate Catholic teachings, such as abortions or sterilizations. In terminating the joint venture, the archdiocese hopes to appease criticism that Caritas would have profited from abortion and other services provided at non-Catholic medical centers, the Boston Globe reports. According to the archdiocese, O"Malley sought the withdrawal after weeks of consultation with the church-affiliated think tank National Catholic Bioethics Center, in response to harsh criticism from antiabortion-rights groups for not blocking the agreement. The withdrawal is "a vindication of sorts" for O"Malley"s critics, who have argued that it would be wrong for Caritas to enter an agreement with a health insurer that covers abortion care, according to the Globe. Andrea Miller, the executive director of NARAL Pro-Choice Massachusetts, said that Caritas" involvement in the joint venture had raised concern from NARAL because of the Catholic Church"s opposition to abortion rights. She said that although Caritas has withdrawn from the venture, "[t]he question remains: Will the involvement of Caritas Christi health providers negatively affect women"s ability to get timely access to reproductive services, including birth control?" Miller added that NARAL hopes that state regulators "will continue due diligence to ensure that referrals and services are provided in a manner that does not delay access to reproductive health services" (Paulson/Lazar, Boston Globe, 6/27).
A federal judge will hear oral arguments on July 17 regarding a lawsuit challenging a South Dakota law that requires doctors to tell women seeking abortions that the procedure will end a human life, the AP/Sioux City Journal reports. Planned Parenthood, which operates the state"s only abortion clinic, appealed the law after it was passed in 2005. U.S. District Judge Karen Schreier temporarily prevented the law from going into effect, but the 8th U.S. Circuit Court of Appeals in July 2008 overruled that order, and the state began enforcing the law. According to the AP/Journal, Schreier will decide during the hearing whether to grant motions for summary judgment and will consider Planned Parenthood"s request to stop the state from imposing sanctions over the law"s requirements (AP/Sioux City Journal, 6/26).
A long-term care program could produce some needed dollars, at least in the short range, CQ Politics reports: "A new insurance program for long-term care that Democrats have included in a Senate health overhaul bill would produce about $58 billion in revenue for the government over the next 10 years, according to the Congressional Budget Office, helping to offset the cost of the legislation. Democrats acknowledge that spending in the long-term care program would increase after 10 years and that it likely would not remain a very profitable enterprise for the government. It is even possible, they say, that the program could become insolvent; in that case, the secretary of Health and Human Services would be authorized to close its enrollment. "The CBO says that premiums would have to rise significantly higher than Democrats have assumed for the program to remain financially sound."
The Miami Herald reports that healthcare reform could acutely affect South Florida and provide both benefits and risks.
Mental health services could be improved by
The recent release of two large randomized trials suggests that if there is a benefit of screening, it is, at best, small, says a new report in CA: A Cancer Journal for Clinicians. Authored by Otis W. Brawley, M.D. of the American Cancer Society and Donna Ankerst, Ph.D. and Ian M. Thompson, M.D. of the University of Texas Health Science Center at San Antonio, the review says because prostate cancer is virtually ubiquitous in men as they age, it is clear that a goal of "finding more cancers" is not acceptable. Instead, public health principles demand that screening must reduce the risk of death from prostate cancer, reduce the suffering from prostate cancer, or reduce health care costs when compared with a non-screening scenario. The authors suggest prostate cancer screening has yet to reach one of these standards to date.
The RCN has responded to the recent (29 June) publication of Building Britain"s Future with Director of RCN England, Tom Sandford, saying of the two week target to see a cancer specialist:
For the first time RCN members can get a unique insight into the International Council of Nurses (ICN) Congress care of a daily blog.
Scientists discover novel mechanism that increases the risk of common colorectal cancer
Diabetes UK has so far encouraged more than 10,000 people in the UK to measure their waists and find out if they are at risk of developing Type 2 diabetes with its national Measure Up Roadshow which kicked off on June 3.
Interest and concern about possible health threats posed by endocrine-disrupting chemicals (EDCs) is on the rise, yet there is currently no comprehensive coordinated approach to regulating EDCs in the United States. To address this emerging public health issue, The Endocrine Society today released a new position statement outlining the public health concerns of exposure to EDCs and proposing a series of recommendations for revising current policy and generating new policy on EDCs.
To be properly diagnosed, retinopathy of prematurity (ROP), the leading cause of childhood blindness in the United States and worldwide, requires a time intensive process and significant coordination between ophthalmologist and NICU staff. A recent study examining ROP diagnosis speed using indirect ophthalmoscopy versus telemedicine, remote medical consultation, is featured in the July issue of the American Journal of Ophthalmology, published by Elsevier.
The influenza virus that wreaked worldwide havoc in 1918-1919 founded a viral dynasty that persists to this day, according to scientists from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. In an article published online on June 29 by the New England Journal of Medicine, authors Anthony S. Fauci, M.D., Jeffery K. Taubenberger, M.D., Ph.D., and David M. Morens, M.D., argue that we have lived in an influenza pandemic era since 1918, and they describe how the novel 2009 H1N1 virus now circling the globe is yet another manifestation of this enduring viral family.
The first microsatellite-based genetic linkage map has been published for Schistosoma mansoni, a blood fluke that is known to infect over 90 million people in Africa, the Middle East and the New World. Researchers writing in BioMed Central"s open access journal Genome Biology hope the map will stimulate research and open doors to new advances in combating this neglected human pathogen.
Physicians have been strongly reminded by the World Medical Association
Helicobacter pylori survives in the body by manipulating important immune system cells. This is shown in a thesis from the Sahlgrenska Academy. The discovery may lead to new treatments against the common peptic ulcer bacterium.
Doctors at the Cedars-Sinai Heart Institute announced today the completion of the first procedure in which a patient"s own heart tissue was used to grow specialized heart stem cells that were then injected back into the patient"s heart in an effort to repair and re-grow healthy muscle in a heart that had been injured by a heart attack. The minimally-invasive procedure was completed on the first patient on Friday, June 26.
New pooled clinical data presented at the 28th International Epilepsy Congress (IEC) in Budapest, Hungary showed that VIMPAT® (lacosamide), a new antiepileptic drug (AED) with a novel mode of action,1,2 significantly improved seizure control, increased seizure freedom rates during the maintenance phase and enhanced quality of life and patient function, when used as adjunctive therapy in adult patients with uncontrolled partial-onset seizures.2,3
Lower extremity peripheral arterial disease (PAD) affects more than eight million Americans, with significant risks of limb loss, disability and death. Treatment of lower extremity PAD focuses on restoring normal blood supply to the affected limb. Traditional treatment, such as surgical bypass, is effective but invasive. In recent years, many patients have been treated with newer endovascular interventions, using catheter-based devices to reopen peripheral arteries in a less-invasive fashion. According to past research, it is unclear if these newer treatments are as effective as conventional surgical bypass in preventing amputation.
Croup is a common respiratory condition characterized by inflammation of the upper airways that often occurs in infants and children. The result is a swelling and narrowing of the larynx (voice box) and trachea (wind pipe) that results in a harsh, barking cough.
The General Optical Council (GOC) is today reminding all optical businesses, students and supervisors to ensure their current arrangements for professional supervision of students meet the requirements outlined by the GOC, and examination or assessment bodies. This follows the recent Fitness to Practise (FTP) hearing involving Boots Opticians Ltd (a GOC-registered business); Trevor Burgess, a registered student dispensing optician; and Richard Simmons, a registered dispensing optician.
Many young smokers want to quit but don"t know what methods work.
The Arthur Labatt Family School of Nursing at The University of Western Ontario has announced a $2 million research chair to address issues surrounding the chronic shortage of registered nurses in Canada and the United States. Dr. Heather Laschinger, Ph.D., was named the first Arthur Labatt Family Nursing Research Chair in Human Re Optimization.
A conservative group wants every lawmaker to pledge to read the entire bill for comprehensive health reform before voting.
Pharmacists Need A Place At The Health Reform Table The Baltimore Sun
A spokesperson from the vaccine manufacturer Roche confirmed reports Monday that a Denmark patient with H1N1 (swine flu) developed resistance to the antiviral Tamiflu, a drug known to decrease the spread and severity of the virus, Reuters reports (Cage/Arnold, 6/29). According to the AP/News & Observer, the patient has since recovered.
The National Pharmacy Association (NPA) and Allergy UK are offering the community pharmacy allergy screening service to members of the public attending the Hampton Court Palace Flower Show from 7 July to 12 July.
Renishaw, a world leader in engineering technologies, is introducing an exciting range of high precision systems for functional and stereotactic neurosurgery at the 15th Quadrennial Meeting of the World Society for Stereotactic and Functional Neurosurgery (WSSFN) taking place in Toronto, Canada, from May 24th to 27th 2009. These include the neuromate® surgical robot, and image-guided stereotactic technologies, some of which are still in development.
The nation"s largest veterinary association applauded four members of the U.S. House of Representatives for introducing legislation that confronts public health threats by investing in the public health veterinary workforce
Daily sex (or ejaculating daily) for seven days improves men"s sperm quality by reducing the amount of DNA damage, according to an Australian study presented to the 25th annual meeting of the European Society of Human Reproduction and Embryology in Amsterdam.
UCB and Biogen Idec announced the discontinuation of the Phase II clinical trial of CDP323 for the treatment of relapsing multiple sclerosis (MS). Preliminary interim efficacy analysis showed that patients enrolled in this clinical trial did not benefit as expected from CDP323 compared to placebo after a six month treatment period. No cases of PML (progressive multifocal leukoencephalopathy) were noted.
Neural stem cells represent the cellular backup of our brain. These cells are capable of self-renewal to form new stem cells or differentiate into neurons, astrocytes or oligodendrocytes. Astrocytes have supportive functions in the environment of neurons, while oligodendrocytes form the myelin layer around axons in order to accelerate neuronal signal transmission. But how does a neural stem cell "know" which way it is supposed to develop? On the molecular level receptors of the Notch family play a significant role in this process. So far, only stimulating extracellular ligands of Notch receptors had been described. Biochemists of Goethe University Medical School now describe a long time assumed but not yet identified soluble Notch inhibitor.
It is based on detecting short, repetitive DNA segments in the genome of bacteria. Every single bacterial strain has such characteristic repeats. "With this method we are able to identify bacterial strains as well as clarify their genetic relationships. Furthermore, we can show how new pathogenic variants develop," says Manfred Hç¶fle, researcher at the HZI. The results have now been published in the current issue of the scientific journal Applied and Environmental Microbiology. The work is part of the two European Union funded projects "Healthy Water" and "AQUA-chip". Manfred Hç¶fle is coordinator of both projects that deal with various aspects of the microbiological safety of both, drinking water and sea water.
A new report from the Institute of Medicine recommends 100 health topics that should get priority attention and funding from a new national research effort to identify which health care services work best. It also spells out actions and res needed to ensure that this comparative effectiveness research initiative will be a sustained effort with a continuous process for updating priorities as needed and that the results are put into clinical practice.
A new report issued by the International Osteoporosis Foundation (IOF) and published in the scientific journal Osteoporosis International1, shows that populations across the globe are suffering from the impact of low levels of vitamin D. The problem is widespread and on the increase, with potentially severe repercussions for overall health and fracture rates.
A front portion of the brain that handles tasks like decision-making also helps decipher different phonetic sounds, according to new Brown University research.
Researchers have found that men and women who feel sensitive to rejection based on their physical appearance are more likely to express interest in having cosmetic surgery than those who are less sensitive to appearance-based rejection. This effect is particularly true when people recall negative comments about their physical appearance.
Lyme disease in the U.S. is caused by the tick-borne bacteria Borrelia burgdorferi and usually begins with a skin lesion, after which the bacteria spread throughout the body to the nervous system, heart or joints. About 60 percent of untreated individuals develop arthritis, which affects the knees in particular. Lyme disease usually responds well to antibiotic therapy, but in rare cases arthritis can persist for months or years after treatment, a rare condition known as antibiotic-refractory Lyme arthritis. Joint fluid usually tests negative for B burgdorferi after treatment, indicating that joint inflammation may persist even after the bacteria has been eradicated.
Aclasta® (zoledronic acid 5 mg)[1] has been approved in the European Union to treat men and post-menopausal women with osteoporosis caused by the long-term use of glucocorticoids, commonly known as steroids.1 The new indication for the treatment of glucocorticoid-induced osteoporosis (GIO) is important because glucocorticoids (often referred to as corticosteroids or steroids) are widely used to treat inflammatory conditions such as asthma, rheumatoid arthritis and inflammatory bowel disease. Patients receiving long-term steroid therapy are at increased risk of fracture, as their use is associated with side effects such as bone loss and consequently osteoporosis.3
Researchers in Berlin, Germany have ameliorated inflammation of the brain in mice caused by immune cells.
There appears to be a link between sleep and weight control, with some studies indicating that sleep disruption can increase weight gain and others that diet affects sleep. Victor Uebele and colleagues, at Merck Research Laboratories, West Point, have now provided further evidence to support this association by showing that T-type calcium channels regulate body weight maintenance and sleep in mice. These data suggest that sleep and circadian treatment approaches may be of benefit in the fight against obesity.
After a series of comprehensive research studies and a governmental research initiative, a respected team of radiation biologists and antioxidant scientists at Premier Micronutrient Corporation has developed BioShield-Radiation® - a patented micronutrient formulation specifically designed to address oxidative stress produced by ionizing radiation.
Today"s 65 year old Medicare Part D beneficiary will be 79 when the coverage gap, or "donut hole," is eliminated, says a new analysis of proposed legislation from the House of Representatives released today by Avalere Health. The firm also concludes that although fewer people will fall into the gap from now until 2023, by 2020 some of the sickest Medicare beneficiaries will spend upwards of $16,000 on drugs before reaching catastrophic coverage where the government covers 95% of their drug costs.
Many low-income women are failing to take the hormonal therapy prescribed as part of their breast cancer treatment, possibly lowering their survival rates, according to a study led by a researcher in the Duke Comprehensive Cancer Center.
A multi-national group of investigators, including a scientist at the University of North Carolina at Chapel Hill, has discovered that nearly a third of the genetic basis of schizophrenia may be attributed to the cumulative actions of thousands of common genetic variants. The effects of each of these genetic changes, innocuous on its own, add up to a significant risk for developing both schizophrenia and bipolar disorder.
What is done when the elderly lodge complaints about their services? elderly care? Why is it that staff describe complaints made by the elderly as "trivialities"? In two recent studies, Tove Persson, doctoral student at the School of Health Sciences, shows that staff, as well as social services directors in local administrations often trivialize complaints from the elderly, which in turn makes it difficult for the elderly to influence their everyday lives.
A new study examining the evolution of maternal mortality rates in Spain since 1996 shows a 17% increase in deaths. This trend is linked to the widespread increase in maternal age. The highest death rates are among foreign women and those who live in the province of Malaga.
The Guardia Pro Protective Embryo Transfer Catheteris uniquely engineered to protect and guide embryos through cervical mucus and blood and to eliminate the need for cervical flushing or aspiration prior to transfer.
UCB announced that the U.S. Food and Drug Administration (FDA) approved Cimzia®, the only PEGylated anti-TNF (Tumor Necrosis Factor), for the treatment of adult patients with moderately to severely active rheumatoid arthritis (RA). Cimzia® can be dosed at 400 mg initially and at weeks two and four, followed by 200 mg every other week; for maintenance dosing, 400 mg every four weeks can be considered.
POZEN Inc. (NASDAQ:POZN), announced the submission of a New Drug Application (NDA) to the U.S. Food and Drug Administration (FDA) for the marketing approval of VIMOVO™ (PN 400), the combination of enteric coated (EC) naproxen and immediate release esomeprazole. POZEN and AstraZeneca entered into a global co-development agreement for VIMOVO in August 2006. Pending regulatory approval, the proposed trade name is VIMOVO and the proposed indications are for the signs and symptoms of osteoarthritis, rheumatoid arthritis and ankylosing spondylitis in patients who are at risk for developing NSAID-associated ulcers.
XenoPort, Inc. (Nasdaq:XNPT) announced positive preliminary results from a Phase 2 clinical trial of arbaclofen placarbil (AP), also known as XP19986, for the treatment of patients with spasticity due to spinal cord injury (SCI). Doses of 20 and 30 mg of AP, given twice daily (BID), demonstrated statistically significant improvements compared to placebo for the primary endpoint of the study. AP was well tolerated during the trial.
"Domestic violence is a serious law enforcement and public health problem affecting as many as one in four women in this country," but "Washington has devoted too little attention to reducing domestic violence and sexual assaults generally," a New York Times editorial states. The editorial continues, "We welcome President Obama"s decision to create a new post, White House adviser on violence against women, and his appointment" of former National Network To End Domestic Violence Executive Director Lynn Rosenthal, "a seasoned advocate for victims to fill it." According to the editorial, Rosenthal will report to Obama and Vice President Joe Biden, "whose keen interest in the issue dates from his days in the Senate and his key role in enacting the 1994 Violence Against Women Act." The "challenge" facing Rosenthal and the Obama administration "will be to improve the carrying out of existing laws intended to protect women, starting with better coordination of the activities of all the government bureaucracies involved," including the Department of Justice, HHS and the Department of Housing and Urban Development, the editorial states. It notes that a national survey of domestic violence shelters released in May found "a significant increase in the number of women seeking assistance since last fall, a rise largely attributable to the stresses of the economic crisis and rising unemployment." The editorial recommends that states create more emergency shelters, establish more transitional housing for "people fleeing violent situations" and "do more to help these victims rebuild their lives." Rosenthal "will need to tackle bureaucratic and legal hurdles and find more money to help states, localities and charitable groups address those needs," the editorial states. In addition, Rosenthal must "help end the scandal of the thousands of rape kits sitting untested in crime labs and police storage facilities across the country, allowing countless criminals to escape punishment." The editorial concludes, "All of this will require strong and creative leadership" from Rosenthal, Biden and Obama (New York Times, 7/1).
Alastair Campbell has won Mind"s Champion of the Year Award for his significant contribution to raising awareness of mental health. He beat fellow nominee and chat show host Paul O"Grady, among other mental health campaigners, to the prestigious award announced yesterday evening.
Medicaid receives increased attention while an underused, special monthly pension benefit called Aid and Attendance can help veterans, and spouses, with assisted living.
The White House sought the help of actor Ashton Kutcher to promote National HIV Testing Day on June 27, through his Twitter page, Politico reports. Kutcher has over 2.5 million followers on Twitter, where he recently posted a link to a White House blog post and video commemorating the day. Reid Cherlin, White House assistant press secretary, said, "As technology impacts how and where people are communicating online, we are constantly looking for new ways to engage with the public," adding, "Our efforts to promote National HIV Testing Day included participation from popular users of Twitter, as well as broad social media engagement by agencies across the government." The White House also used Twitter to help connect people to HIV testing sites (Gavin, 6/29).
Deadly diseases including plague, Ebola and Rift Valley Fever are being targeted as part of a new multi-million pound international partnership involving African researchers and the London International Development Centre (LIDC). The Southern African Centre for Infectious Disease Surveillance (SACIDS) links medical and veterinary institutions from five African countries and the UK to improve the capacity of African institutions to detect, identify and monitor infectious diseases affecting humans and animals, including new infectious human diseases of animal origin.
Summer is the season for sizzling - steaks, chicken, ribs, veggie kabobs and much more. The Connecticut Department of Public Health reminds everyone that food safety is essential when grilling outdoors and offers tips to ensure that family barbecues and backyard picnics remain fun, healthy outings.
Counseling patients with non-alcoholic fatty liver disease (NAFLD) on how to increase physical activity leads to health benefits that are independent of changes in weight. These findings are in a new study in the July issue of Hepatology, a journal published by John Wiley & Sons on behalf of the American Association for the Study of Liver Diseases (AASLD). The article is also available online at Wiley Interscience.
Aging adults living in nursing homes and relying on the care of others are often susceptible to a long list of medical problems. These problems are debilitating for the residents and cost facilities millions of dollars. In a new study, a University of Missouri researcher found that long-term care facilities in Missouri saved more than $6 million in the past three years after implementing a quality care improvement program. Savings for the facilities were more than 10 times the program costs.
An otherwise effective treatment for cystic fibrosis places patients at a high risk of sensorineural hearing loss, according to new research published in the July edition of Otolaryngology-Head and Neck Surgery.
A research team at Northwestern University has demonstrated a tool that can precisely deliver tiny doses of drug-carrying nanomaterials to individual cells.
Scientists in the UK and Denmark have shown that if elderly men were given growth hormone and exercised their legs showed an appreciable muscle mass increase. Dr. Geoff Goldspink (Royal Free and University College Medical School, UK) says: "This raises the question: Can age-related loss of muscle strength and increased fragility be ameliorated by the therapeutic application of mechano growth factor (MGF)?". There is hope that MGF can also help sufferers of diseases such as muscular dystrophy, ALS, renal disease or cancer, for whom intensive exercise is not an option. It may even prove useful to ameliorate muscle loss resulting from long periods in zero-gravity conditions during space travel. Dr. Mark Lewis (University College London, UK) will present their latest results on how MGF exerts its effects during his talk at the Society of Experimental Biology Annual Meeting in Glasgow.
A team of Penn State scientists has shed light on the processes that lead to certain human DNA mutations that are implicated in hundreds of inherited diseases such as tuberous sclerosis and neurofibromatosis type 1. The results one day could influence the way couples who seek to have children receive genetic counseling. The team, led by Kateryna Makova, an associate professor of biology, also includes Erika Kvikstad, a graduate student in the Department of Biology, and Francesca Chiaromonte, an associate professor of statistics. Their findings will be published in the July 2009 issue of the journal Genome Research.
Critical Outcome Technologies Inc. (TSX VENTURE:COT), announced positive results today from combination agent animal experiments carried out at a prominent American cancer research facility. The results provide strong supportive evidence for the continued evaluation of COTI-2 in combination with conventional single agent therapy for the treatment of ovarian cancer:
Acura Pharmaceuticals, Inc. (Nasdaq: ACUR) and King Pharmaceuticals, Inc. (NYSE: KG) announced today that the U.S. Food and Drug Administration (FDA) has issued a Complete Response Letter regarding the New Drug Application (NDA) for Acurox (oxycodone HC1, USP and niacin, USP) Tablets CII, an immediate release product intended for the relief of moderate-to-severe pain.
Researchers of the Department of Neuroscience and Health Sciences of the University of AlmerÃa and Hospital Torrecárdenas are carrying out an assessment of the physical neuropsychological characteristics of children born before 32 weeks" gestation or whose weight is lower than 1500 grams -very premature-. The main aim of this project, coordinated by M Dolores Roldán Tapia, from the UAL, is to accurately define the origin of brain damage, so as to stimulate the affected area early thus causing the adequate cognitive and motric development of the individual.
A revolutionary new device which could save the lives of stroke patients has been developed by a University of Wolverhampton expert.
This Saturday 4th July not only marks the beginning of National Transplant Week, but is also Team UK"s last training meet before they jet off to the World Transplant Games in Australia, helping to raise awareness of the ongoing need for organ donors and encourage people to sign up to the Organ Donor register. Lending support for this year"s team in Australia will be David Moorcroft, patron of both the British Transplant Games and Team UK. Moorcroft aims to give his moral support to Team UK, as well as invaluable last-minute tips.
Curcumin, the major polyphenol found in turmeric, appears to reduce weight gain in mice and suppress the growth of fat tissue in mice and cell models. Researchers at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University (USDA HNRCA) studied mice fed high fat diets supplemented with curcumin and cell cultures incubated with curcumin.
In an effort to encourage medical professionals to provide services to low-income rural populations in India, Union Health and Family Welfare Minister Ghulam Nabi Azad announced an initiative that will significantly raise the salary of "doctors, specialists and para-medical staff" who elect to work in "rural, particularly far-flung and inaccessible areas," the Hindu reports.
Democrats on a key Senate committee are readying a plan that has a government-run insurance option and a $750-per-worker annual fee on larger companies that do not offer coverage to its employees, The Associated Press reports.
President Obama reiterated his call to adjust Medicare reimbursement rates as a part of his broad push for health reform in a meeting with nine reporters, including writers from local newspapers, Wednesday. "While steering clear of details, Obama indicated that revised reimbursement rates helpful to areas [where reimbursement rates are low] should be part of a comprehensive healthcare reform package now in the works," McClatchy reports. "The reforms should also help steer more physicians to medically underserved regions, he said," achieve better quality, and lower government payments. The news service notes that the meeting was "part of [Obama"s] effort to rally political support for a healthcare rewrite. The package is still a work in progress, as key congressional committees already have missed their self-imposed legislative deadlines" (Doyle, 7/1).
Doctors and nurses consider job security and the differences between primary care and specialties when choosing their career paths.
The opening of a unique centre will put Newcastle at the forefront of cancer research and bring benefits to patients in the North East.
Skin from a factory - this has long been the dream of pharmacologists, chemists and doctors. Research has an urgent need for large quantities of "skin models", which can be used to determine if products such as creams and soaps, cleaning agents, medicines and adhesive bandages are compatible with skin, or if they instead will lead to irritation or allergic reactions for the consumer. Such test results are seen as more meaningful than those from animal experiments, and can even make such experiments largely superfluous.
Psychologists representing the American Psychological Association joined other invited health care practitioners, leaders and aides to President Obama today for the latest White House Stakeholder Discussion Group, emphasizing that health reform must include psychological services as part of primary care.