Public Health
The U.S. Food and Drug Administration approved a total ankle replacement system for arthritic or deformed ankles that may preserve some range of motion in the joint.
The criteria used to assess blood alcohol concentrations (BACs) and binge drinking behaviors in children and adolescents should be based on pediatric rather than adult physiology, according to a new University of Pittsburgh study in the June issue of Pediatrics.
UnitedHealth Group"s Center for Health Reform and Modernization on Wednesday suggested 15 steps that could be taken to save $540 billion in federal in health care costs over the next 10 years, the AP/Seattle Post-Intelligencer reports (Werner, AP/Seattle Post-Intelligencer, 5/27). Simon Stevens, head of the center, said that the report "puts some flesh on the bones" of the pledge made by health care industry groups earlier this month to cut health care costs, noting that the recommendations already are being used by UnitedHealth to reduce costs and can be applied to Medicare (Reuters, 5/27).The recommended steps include:
ProTrials Research, Inc.TM, a leader in the clinical research organization industry, announced Medivation, Inc. (NASDAQ:MDVN) has chosen the company to conduct separate international Phase III clinical trials for two novel treatments. ProTrials will test MDV3100 for treating prostate cancer and the investigational drug Dimebon TM as a treatment for Huntington"s disease. Due to the complex nature of these Phase III trials, Medivation again selected ProTrials as its contract research organization partner because of ProTrials" successful past performance with the company"s Phase I, II and III trials.
Napo Pharmaceuticals, Inc. ("Napo") is proud to announce that the Company is part of the Call to Action led by PATH, UNICEF, and WHO to raise the visibility of diarrheal disease and solutions to address it. The Call to Action includes the invitation to "invest in the research and development of new effective, appropriate and affordable prevention and treatment options for diarrheal disease."
International Stem Cell Corporation (OTCBB:ISCO), the first company to perfect a method of creating human "parthenogenetic" stem cells from unfertilized eggs, has received positive early results from animal trials designed to improve photorefractive keratectomy (PRK), a form of corrective laser eye surgery that offers an improved alternative to LASIK.
In what could be a major pharmaceutical breakthrough, research published online in The FASEB Journal describes how scientists from St George"s, University of London have devised a one-two punch to stop HIV. First the report describes a new protein that can kill the virus when used as a microbicide. Then the report shows how it might be possible to manufacture this protein in quantities large enough to make it affordable for people in developing countries.
As the best drugs become increasingly resistant to superbugs, McMaster University researchers have discovered a completely different way of looking for a new antibiotic.
Oxoid, a world leading microbiology brand, has today announced the availability of two new chromogenic media in the Brilliance™ Resistant Screening Agar range. Brilliance ESBL Agar and Brilliance VRE Agar can be used as screening tests to rapidly identify patients colonised with problematic Extended Spectrum Beta-Lactamase (ESBL) producing organisms and vancomycin resistant enterococci (VRE), allowing appropriate infection control and treatment to commence sooner for the best possible patient outcome.
When someone becomes dependent on drugs or alcohol, the brain"s pleasure center gets hijacked, disrupting the normal functioning of its reward circuitry.
A home-based diet and exercise program reduced the rate of functional decline among older, overweight long-term survivors of colorectal, breast and prostate cancer, according to a study in the May 13 issue of JAMA.
A new study appearing in Congestive Heart Failure has found that the presence of anemia in patients with chronic heart failure is associated with a significantly increased risk of death. The findings also show that anemia is associated with a poorer degree of left ventricular function and a lower left ventricular ejection fraction, an objective measure of cardiac function.
Men with systolic chronic heart failure who have low or high levels of estradiol, a form of the hormone estrogen, have an increased risk of death compared with men with moderate levels of this hormone, according to a study in the May 13 issue of JAMA.
Small Bone Innovations, Inc. (SBi), a leading provider of innovation, products, technology and education for the small bone & joint segment of the orthopedics industry, announced that the U.S. Food and Drug Administration (FDA) has approved SBi"s Scandinavian Total Ankle Replacement (S.T.A.R.®) system to treat U.S. patients. S.T.A.R. has received pre-market approval (PMA) to replace a painful arthritic ankle joint due to osteoarthritis, post-traumatic arthritis or rheumatoid arthritis.
Midwifery Regulators from eighteen European countries have met in London to discuss ways in which they can collaborate to enhance the safety of women and babies across the EU.
Perceptive Informatics, the industry"s leading eClinical solutions provider and a subsidiary of PAREXEL International Corporation (Nasdaq: PRXL), announced the launch of a website designed to help investigators apply the new 1.1 version of RECIST (Response Evaluation Criteria In Solid Tumors) in medical imaging-based oncology trials.
For the past century, changes in the Western diet have altered the consumption of omega-6 fatty acids (w6, found in meat and vegetable oils) compared with omega-3 fatty acids (w3, found in flax and fish oil). Many studies seem to indicate this shift has brought about an increased risk of inflammation (associated with autoimmunity and allergy), and now using a controlled diet study with human volunteers, researchers may have teased out a biological basis for these reported changes.
A new study is the first to show that there is a previously unrecognized role for environmental pollution in liver disease in the general U.S. adult population. This work builds upon the groups" previous research demonstrating liver disease in highly-exposed chemical workers. The study is being presented during Digestive Disease Week® 2009 (DDW®), the largest international gathering of physicians and researchers in the fields of gastroenterology, hepatology, endoscopy and gastrointestinal surgery.
The FDA is ignoring critical information in deciding whether to approve an over-the-counter, rapid HIV test for home use, according to a recent article in the journal Medical Decision Making (MDM) which is published by SAGE.
The Nebraska Legislature on Wednesday voted to advance a bill (L.B. 675) that would require abortion providers who perform ultrasounds on women seeking the procedure to tell women that a view of the fetus will be available and display the screen in a way that the image can be easily seen, the AP/Lincoln Journal Star reports. The bill also would require the state to compile a list of clinics that offer no-cost ultrasound services. State Sen. Brenda Council (D) criticized that particular provision, saying it would force the state Department of Health and Human Services to spend more taxpayer money.Lawmakers advanced the bill by voice vote after approving an amendment to clarify language surrounding the qualifications of health professionals performing ultrasounds. Advocates for the bill claim it would provide more information to women seeking abortion procedures, while opponents of the bill argue that it would allow the government to interfere in a private procedure. The bill faces a final vote before going to Gov. Dave Heineman (R). If the bill becomes law, Nebraska would join more than a dozen states that have similar laws, the AP/Journal Star reports (Ortiz, AP/Lincoln Journal Star, 5/27).
Congressional lawmakers who are crafting a plan to overhaul the U.S. health care system might be able to look to state health insurance programs in Massachusetts and Tennessee for ideas, the AP/Minneapolis Star Tribune reports. Health reform legislation modeled after Massachusetts" near-universal health insurance law "is likely to emerge" in Congress, "although details remain unsettled," the AP/Star Tribune reports. The plan also could include components of Tennessee"s CoverTN program, which charges beneficiaries who smoke or are overweight higher premiums. Lawmakers in the Senate already have discussed a lifestyle tax funding mechanism, such as taxes on alcohol and sugary beverages. According to AP/Star Tribune, Massachusetts "chose to cover virtually everyone," while Tennessee "chose to get just a few more people bare-bones insurance at a budget price with limits on how much plans would pay for hospital stays."Alan Weil of the National Academy for State Health Policy said, "The belief that we should all have health insurance coverage is broadly held," but "there are tremendous differences around the country in beliefs on how to achieve that goal." He added, "We learn from Massachusetts that a bold objective matters. If it can be sustained, that"s terrific," and "[i]t would be nice if you had a southern state that had achieved universal coverage and did it in a different way, but we don"t have that" (Johnson, AP/Minneapolis Star Tribune, 5/28).
A case report written by Dr Francesco Natale and his colleagues, from the Second University of Naples and Monaldi Hospital, Naples, Italy, reports on the dangers of stimulant chewing gums containing caffeine. The report published in this week÷´s edition of The Lancet describes the story of a teenage boy hospitalized after excessive consumption of this type of product. The authors warn about the high risks of stimulant chewing gums that are widely available to children.
The New York Stem Cell Foundation (NYSCF) announced the award of four new NSYCF-Stanley and Fiona Druckenmiller Fellows. These New York-based post-doctoral scientists join 13 extraordinarily accomplished stem cell researchers from leading research institutions who have been supported by the fellowships program since 2006.
Varian Medical Systems, Inc. (NYSE: VAR) X-Ray Products, a world leader in X-ray tubes and supplier of the premier PaxScan® line of digital X-ray image detectors for filmless X-rays, has introduced their first digital imager specifically designed for interventional angiography procedures.
A new article published in Elsevier"s journal Bioscience Hypotheses suggests that our feelings in our lifetime can affect our children.
Patients with inflammatory arthritis completing a health-related quality of life questionnaire report levels of pain that result in their health being rated as "worse than death" by members of the general population.
Professor Til Wykes is to receive the 2009 M.B. Shapiro Award from the British Psychological Society"s Division of Clinical Psychology. It is the Division"s premier award and is made each year to a clinical psychologist who has achieved eminence in the profession.
Studies overwhelmingly point to regular physical exercise as the crucial medicine for what ails Americans. Physicians have a hard time convincing even healthy patients to take action, but it"s a much harder sell for those with limited movement caused by physical disabilities. They often lack the self-confidence to begin a physical fitness plan, and it"s easy to understand why. They face transportation obstacles to visit an exercise facility. If they can get to the facility, accessing the building and equipment is often difficult or impossible, and fees are often high, says Dr. Zibin Guo, a medical anthropologist in The University of Tennessee at Chattanooga Department of Sociology, Anthropology, and Geography. He says appropriate and interesting exercise is often not available to this group.
A new surgical technique could allow surgeons to perform a radical hysterectomy in patients with early-stage cervical cancer-with fewer complications, reduced morbidity, and a lower risk of local tumour recurrence than current surgical methods, according to an Article published Online first and in the July edition of The Lancet Oncology.
A new pill that contains a potent version of the naturally occurring compound lycopene, a carotenoid found in tomatoes and other fruits and
Clive N. Svendsen, joint leader of the widely-respected Stem Cell and Regenerative Medicine Center at the University of Wisconsin, has been named director of the new Cedars-Sinai Regenerative Medicine Institute, effective Dec. 1, 2009.
New Phase III study results presented for the first time at the ninth annual American Transplant Congress 2009 (ATC) demonstrate that doubling the duration of preventive therapy ("prophylaxis") with Valcyte (oral valganciclovir) significantly reduced the incidence of CMV disease by 56% in high-risk kidney transplant patients within the first year post-transplant.
New research quantifies the precise effects of environmental pollutants and alcohol intake on gastrointestinal (GI) health. Both studies being presented this week during Digestive Disease Week® 2009 (DDW®) offer concrete evidence that the environment and alcohol intake can affect GI health and share important insights into new directions for future research. DDW is the largest international gathering of physicians and researchers in the fields of gastroenterology, hepatology, endoscopy and gastrointestinal surgery.
The Long Path to Diagnosis
With healthcare expenses and despite rising unemployment, the vitamin industry is seeing significant growth. Code Nutrition, a leader in personalized, high quality nutritional supplements, is helping people cut health care costs while maintaining or improving their health, by providing supplements based on personalized genetic testing and lifestyle information.
Mayo Clinic researchers have shown that very low doses of inhaled carbon monoxide in diabetic mice reverses the condition known as gastroparesis or delayed stomach emptying, a common and painful complication for many diabetic patients. The findings were presented on June 1 at Digestive Disease Week in Chicago.
The next meeting of the General Dental Council (GDC) will take place on Thursday 11 June 2009 in the Harvey Goodwin Room, Church House Conference Centre, Dean"s Yard, Westminster, London, SW1P 3NZ from 10:30am.
Catholic constitutional law professors Doug Kmiec of the Pepperdine University School of Law and Robert George of Princeton University on Thursday during a forum at the National Press Club debated the Obama administration"s abortion policies and whether opposing sides in the abortion-rights debate should work toward finding "common ground," the Washington Times reports. Kmiec -- a Republican who broke rank with many Catholics and supported President Obama"s run for the presidency -- stressed that the president is serious about reducing the need for abortion. However, George "challenged the administration to do something concrete," such as ban certain abortion procedures, according to the Times. He said that Obama "rejects what we and pro-lifers propose is common ground. ... He does not believe human beings acquire rights until after birth."Kmiec and George also debated the role of Catholics in politics, such as whether Catholics who support abortion rights should be denied Holy Communion or whether Catholic bishops should speak out against politicians who support abortion rights. In April 2008, a Los Angeles priest denied Kmiec Communion because of his support for Obama. Kmiec asked, "Are we as Catholics expected to sit on the sidelines aloof with the truth talking to ourselves or are we to engage our fellow citizens and offer that faith? The 2008 election was very much a test of that." He said that he does not believe that intimidation is the correct way to address abortion-rights issues, adding that the "denial of Communion is intimidation." Kmiec said that Catholic bishops" opposition to abortion-rights supporters who are Catholic "is not either an effective nor a Catholic approach. Nor is it a Catholic approach to endorse candidates. Yet certain bishops endorse candidates. Nor should churches allow materials in their vestibule saying it is a sin of the highest order to cast a vote for Barack Obama." He noted that 54% of Catholics voted for Obama.George opted to focus on Obama"s legislative record instead of the issue of Catholics in politics. He said, "Obama"s record as an activist, legislator and now as president is that an unborn baby possesses no rights. Throughout his career, he has denied every fundamental legislation that would discourage its practice or limit its liability" (Duin, Washington Times, 5/29).
The world"s largest ear, nose, and throat professional medical association, the American Academy of Otolaryngology - Head and Neck Surgery (AAO-HNS), has released a manual detailing best practices for the creation of new clinical practice guidelines. The manual is published as a supplement to the June issue of Otolaryngology - Head and Neck Surgery.
A team led by scientists at The Institute of Cancer Research (ICR) compared the genes of 730 men who had developed testicular cancer with the genes of healthy men. They found many of the men who had suffered cancer shared common DNA variants on chromosomes 5, 6 and 12 that the healthy men did not have.
Findings in mice suggest greater hope for targeting brain cancer, but also greater caution in pursuing stem cell treatments for degenerative diseases
Oligophrenin-1, a Rho-GTPase-activating protein, stabilizes postsynaptic AMPA receptors
More than 17 million U.S. children live more than an hour away by ground or air transportation from a life-saving pediatric trauma center, according to a new study by researchers at The Children"s Hospital of Philadelphia and the University of Pennsylvania. The creation of a national inventory of pediatric trauma centers may help to identify the locations of gaps and greatly improve access to care for U.S. children, the authors said.
The four-type (6, 11, 16, 18) human papillomavirus (HPV) vaccine,
Soccer players and exercise enthusiasts now have another reason to reach for lowfat chocolate milk after a hard workout, suggests a new study from James Madison University presented at the American College of Sports Medicine annual meeting. Post-exercise consumption of lowfat chocolate milk was found to provide equal or possibly superior muscle recovery compared to a high-carbohydrate recovery beverage with the same amount of calories.
The following statistics were released by the Department of Health:
The United Kingdom"s National Institute for Health and Clinical Excellence (NICE) has published a Final Appraisal Determination (FAD) recommending the use of the drug Erbitux® (cetuximab) in combination with chemotherapy as a 1st-line treatment for patients with metastatic (advanced) colorectal cancer (mCRC) who have met specific additional criteria1 - presenting the possibility of potentially curative surgery.2 The treatment is recommended for patients in whom the cancer has spread only to the liver and who have normal or "wild-type" KRAS tumors.1 In the UK, a recommendation by NICE is a prerequisite for funding of a medical treatment by the National Health Service.
Rheumatoid arthritis (RA), the most common form of inflammatory arthritis, affects almost three percent of people over age 65. RA patients experience pain, functional limitations and two forms of disabling bone disease: focal erosions and osteoporosis. After five years of disease, up to 50 percent of RA patients show evidence of focal erosions and RA doubles the risk of osteoporosis and fractures. A new study examined the relationship between these two RA-related processes, in the hopes of providing insight into the underlying pathophysiology of RA-related bone disease. The study was published in the June issue of Arthritis & Rheumatism.
ZIOPHARM Oncology, Inc. (Nasdaq: ZIOP) announced that it presented final data from a Phase I study of palifosfamide (ZymafosTM) in combination with doxorubicin at the 45th Annual American Society of Clinical Oncology (ASCO) meeting held in Orlando, FL, May 29th to June 2nd.
Virginia Commonwealth University researchers have identified a gene that may play a key role in regulating tumor progression in neuroblastoma, a form of cancer usually found in young children. Scientists hope the finding could lead to an effective therapy to inhibit the expression of this gene.
As the number of food and beverage products sweetened with stevia-based ingredients continues to grow in the United States and worldwide, the U.S. Pharmacopeial (USP) Convention announces that new reference standards for Rebaudioside A and Stevioside are now available. The reference standards for these two ingredients complement the soon to be released written testing standard for high-purity Rebaudioside A in the Food Chemicals Codex (FCC), a collection of documentary standards for food ingredients that allow manufacturers to demonstrate the quality, and thus related aspects of safety, of the products they provide to consumers.
We want our husbands, fathers, brothers, uncles and grandfathers, all indispensable parts of our families, to live long, healthy lives. Reliv International nutritional supplements can help them do just that. Distributors of Reliv supplements are honoring National Men"s Health Week, June 15th to June 21st, by offering tips on how men can step up their healthy defenses.
Shire plc (LSE: SHP, NASDAQ: SHPGY), the global specialty biopharmaceutical company, has announced that the US Food and Drug Administration (FDA) has approved a change to the prescribing information for its once-daily Attention Deficit Hyperactivity Disorder (ADHD) treatment VYVANSE® (lisdexamfetamine dimesylate) CII, to include supplemental data that demonstrated significant ADHD symptom control in children aged 6 to 12 from the first time point measured (1.5 hours) through 13 hours postdose. VYVANSE is now the first and only oral ADHD stimulant treatment to have 13-hour postdose efficacy data for pediatric patients included in its product labeling.
National Allergy Week 11-15 May 2009
A team of University of Minnesota-Twin Cities students from a civil engineering class will head to India later this month to share their ideas and plans for helping bring clean water to thousands of residents living in the slums of Mumbai - the same impoverished area that provided the backdrop for the 2009 Oscar Award-winning movie, "Slumdog Millionaire."
Genta Incorporated (OTCBB: GNTA.OB) announced preliminary results from its ongoing clinical study of tesetaxel, a leading oral taxane in the Company"s investigational drug portfolio. The new data show a favorable safety profile with a low incidence of serious adverse events, along with objective responses that have been observed at less than the maximally tolerated dose (MTD). The data are featured in a presentation today at the annual meeting of the American Society of Clinical Oncology (ASCO) in Orlando, FL.
Health officials on Sunday said that a diarrhea outbreak has spread across Bangladesh"s southwest due to the effects of Cyclone Aila, which hit parts of Bangladesh and India on May 25, AFP/Google.com reports. Diarrhea broke out at an "alarming rate" because inundation and water logging have destroyed large amounts of land and supplies of drinking water near Sundarbans, the world"s largest mangrove forest, according to health workers.
Teens and children with autism spectrum disorders who were given citalopram, an antidepressant, experienced no change in their repetitive behaviors, according to a study reported in Archives of General Psychiatry. Repetitive behaviors are common among people with autism, as are inflexible routines, which sometimes interfere with everyday life.
The Santa Maria Times examines how California Gov. Arnold Schwarzenegger"s (R) plan to reduce state spending by more than $5 billion over the next two fiscal years, which includes millions of dollars in funding cuts to HIV prevention, education and treatment programs, could affect county residents (Womack, Santa Maria Times, 5/31). According to the Times, hundreds of residents in Santa Barbara County -- including more than 100 AIDS Drug Assistance Program (ADAP) clients -- would potentially be affected by the funding cuts (Santa Maria Times, 5/31). The proposal also would result in $1.8 million in cuts to programs for low-income residents living with HIV in Riverside County, the Desert Sun reports (Brambila, Desert Sun, 5/29). The plan, issued by Schwarzenegger last week, includes $55.5 million in cuts to California"s ADAP and other state Office of AIDS programs (Kaiser Daily HIV/AIDS Report, 5/27).
Somerset people living in the Williton area now have a wider choice when it comes to choosing an NHS dentist.
A paper published in the Proceedings of the National Academy of Sciences by Tufts Medical Center and Tufts University researchers reports that amniotic fluid surrounding Down syndrome fetuses shows oxidative stress, a condition that could harm fetal cells and play a role in affected individuals. The results demonstrate secondary adverse consequences of Down syndrome and suggest potential prenatal therapies.
Hyperion Therapeutics, Inc. announced top-line results from a phase I study of HPN-100 in patients with liver cirrhosis. The data were presented as part of the 2009 Digestive Disease Week meeting. The abstract is titled "Pharmacokinetic (PK) and Safety Analyses of a Novel Ammonia-Reducing Agent in Healthy Adults and Patients with Cirrhosis."
Clinical trial results presented at the Digestive Disease Week in Chicago reveal that endoscopic radiofrequency ablation performed in a community practice setting is safe and effective for eradicating a pre-cancerous esophageal condition known as Barrett"s esophagus. The study is entitled, "Radiofrequency Ablation of Barrett Esophagus: Outcomes of 429 Patients from a Multi-center Community Practice Registry" and was presented today by Ronald E. Pruitt, M.D., Nashville, TN, at a scientific session sponsored by the American Society of Gastrointestinal Endoscopy.
B. Braun Medical Inc. (B. Braun), a leader in infusion therapy and pain management, said today it anticipates U.S. Food and Drug Administration (FDA) approval for 2g Cefazolin for Injection USP and Dextrose Injection USP in B. Braun"s DUPLEX(R) Drug Delivery System.
CSC (NYSE: CSC) announced that it has expanded its FirstPortfolio solution"s business process outsourcing (BPO) capabilities to include fully integrated Medicare Secondary Payer (MSP) reporting for healthcare payers. FirstPortfolio provides users with a collection of applications hosted and maintained by CSC.
When should a parent schedule a comprehensive eye assessment for a baby? Clinical research has shown that at 6 months, the average baby has reached a number of critical developmental milestones, making this an appropriate age for the first eye and vision assessment.
Reuters reports that, due to the difficulties in getting or paying for health insurance, "countless workers in the United States are trapped in jobs they would like to leave ... calcifying innovation and mobility in the world"s largest economy." Reuters notes that when he was head of the National Federation of Independent Businesses, "Todd Stottlemeyer frequently encountered would-be entrepreneurs who let their ideas go stale and their products languish on the workbench because they did not want to shoulder their own health care costs. "
In the midst of Zimbabwe"s growing humanitarian crisis, U.N. agencies on Monday released a revised statement of appeal for foreign donations totaling $718 million for "food, clean water, AIDS medicines and other aid - up from an estimate of $550 million in November," the AP/Washington Post reports (Shaw, AP/Washington Post, 6/1).
Bayer Schering
The Nigerian government believes that by 2013 malaria will cease to be a major public health problem in the country because families will have universal access to prevention and treatment, which will ultimately lead to malaria eradication in Nigeria, according to a document prepared by the National Malaria Control Program of the Federal Ministry of Health in Abuja, Nigeria, Xinhua reports.
Targeting the issue of low birth rates, the Taiwanese government implemented the Mega Warmth Social Welfare Program (MWSWP) in 2006 after its fertility rates dipped lower than most industrial nations.
International development charity Teaching-aids At Low Cost (TALC) has launched the 10th edition of its e-TALC CD.
The same techniques used to detect suspicious activity in airports, stadiums and other public places are now being used by the UCF researcher who invented them to find and measure potentially life-threatening brain tumors.
Cardiovascular disease (CVD), the leading killer in the United States, is a major public health issue contributing to 2,400 deaths each day. Periodontal disease, a chronic inflammatory disease that destroys the bone and tissues that support the teeth affects nearly 75 percent of Americans and is the major cause of adult tooth loss. While the prevalence rates of these disease states seem grim, research suggests that managing one disease may reduce the risk for the other.
External beam partial breast irradiation (EB-PBI) is the most cost-effective method for treating postmenopausal women with early-stage breast cancer based on utilities, recurrence risks and costs when compared to whole breast radiotherapy (WBRT) and brachytherapy partial breast irradiation (brachy-PBI), according to a study in the June 1 issue of the International Journal of Radiation Oncology*Biology*Physics, the official journal of the American Society for Radiation Oncology (ASTRO).
Data from the Phase III ZODIAC1 study in advanced non-small cell lung cancer patients, with the investigational drug vandetanib, were presented today at the American Society of Clinical Oncology (ASCO) meeting in Orlando. Results show that the study met its primary endpoint, demonstrating that the addition of vandetanib to docetaxel resulted in a statistically significant improvement in progression-free survival (PFS), the length of time a patient lives without their cancer growing (hazard ratio [HR] 0.79, 97.58% CI 0.70-0.90; PAbout vandetanib
Dr Peter O"Meara, Associate Professor in Pre-hospital Care at Charles Sturt University in Australia, is the first non-UK paramedic to be appointed to a three year visiting Professor post in the UK in the subject of Pre-Hospital Care.
Data presented at the American Society of Clinical Oncology (ASCO) 2009 meeting, in Orlando, Florida, show that bevacizumab (Avastin®) plus commonly used chemotherapies increases the chance of the patient living without the disease worsening by up to 36% compared to chemotherapies alone, in women receiving first-line therapy for advanced HER2-negative breast cancer. The Phase III RIBBON-1 study combined bevacizumab with chemotherapies, including capecitabine (Xeloda®), taxanes and anthracyclines and measured progression-free survival (PFS).1 No new safety signals for bevacizumab were observed in the study.
Working with a population of individuals at risk for gastrointestinal cancers, researchers at Fox Chase Cancer Center have learned that many people misjudge their actual degree of cancer risk and, therefore, their true need for prevention support. Strategies for accurately assessing cancer risk are critical for appropriately targeting educational, counseling, and diagnostic res to prevent cancer in as many individuals as possible, the investigators say.
A recent clinical trial - led by Goshen Center for Cancer Care - has yielded promising results for the future use of a cancer vaccine. One of the first studies to prove vaccines might have a medical benefit against cancer, study results found the new cancer vaccine doubled the response rate for tumor shrinkage as well as delayed the progression of cancer in patients with metastatic melanoma.
Call it advanced warfare on the most elemental of levels.
- 1 confirmed case in Wales (a 31 year old male from the Caerphilly local authority area. He has had mild flu symptoms, has been offered antivirals and is recovering at home).
Sunwin International Neutraceuticals, Inc. (OTCBB: SUWN), a leader in the production and distribution of Chinese herbs, veterinary medicines and one of the world"s leading producers of all natural, zero calorie Stevia in China, announced today that the company has increased the availability of two veterinary medicines, Huangqiduotang vaccine and Jinfang Detoxification Powder to treat swine flu that has recently spread in North America and other parts of the world. These products, currently used for controlling various types of influenza in China, have demonstrated effectiveness in controlling swine flu outbreaks among livestock.
The European Society of Cardiology Congress 2009, the world"s biggest international meeting in Cardiology will be held in Barcelona, Spain, from 29 August to 2 September.
Results from a number of clinical trials were presented during the Digestive Disease Week (DDW) in Chicago this week, revealing new outcomes data related to endoscopic radiofrequency ablation using the HALO ablation system for eradicating a pre-cancerous esophageal condition known as Barrett"s esophagus. Among them, reports included durability outcomes from a randomized sham-controlled trial, safety and efficacy outcomes from a large U.S. registry of 429 patients, a randomized trial comparing ablation to endoscopic resection, and the largest European series to date in patients with high-grade dysplasia and early cancer.
Supreme Court nominee Sonia Sotomayor on Tuesday met individually with 10 senators in an initial round of closed-door meetings in preparation for her confirmation hearing, which is yet to be scheduled, the New York Times reports. Senate Judiciary Committee Chair Patrick Leahy (D-Vt.) said that during his meeting with Sotomayor she expressed her belief that ""ultimately and completely" a judge has to follow the law no matter what their upbringing has been" (Herszenhorn/Hulse, New York Times, 6/3). Sen. Dianne Feinstein (D-Calif.), who also met with Sotomayor, said that she believes that Sotomayor would not vote to overturn Roe v. Wade. Feinstein added that Sotomayor "is a woman who is well-steeped in law and well-steeped in precedent. I believe that she has a real respect for precedent and that she was not just saying that" (Isenstadt, Politico, 6/2). Senate Majority Leader Harry Reid (D-Nev.) said of Sotomayor, "We have the whole package here," adding, "We could not have anyone more qualified" (New York Times, 6/3).However, Senate Judiciary Committee ranking member Jeff Sessions (R-Ala.), who also met with Sotomayor, said that he is concerned about whether Sotomayor would be an "activist" judge who believes her role is to create policy rather than to judge matters in accordance with it. Sessions said that "the question is, what is the law? How does a judge find the law, and what approach to statutory construction do they utilize?" (Hirschfield Davis, AP/Washington Times, 6/2). According to the Times, because Republicans likely do not have the votes to use a filibuster to block Sotomayor"s confirmation, their strategy "seems to be to play for time," in the hope that "something unexpected" will surface as a threat to her confirmation. Democrats currently have 59 of the 60 votes needed to stop a filibuster, and seven Republicans voted to confirm Sotomayor to the appeals court (New York Times, 6/3). The Judicial Confirmation Network, a conservative judicial group, on Tuesday sent a letter to every senator criticizing Sotomayor"s judicial record and saying that she "challenges the belief that the law needs to be knowable and predictable." JCN Director Gary Marx said that the organization does not agree with other conservative groups that have called for a filibuster but that it supports "a long and vigorous and thorough, healthy debate" (Palmer, Roll Call, 6/2). Leahy, Sessions To Discuss Hearing Schedule Leahy said that he and Sessions will meet Wednesday to discuss a schedule for Sotomayor"s confirmation hearing, specifically with regard to whether it will come before or after the August congressional recess. Leahy said that he favors holding the hearing in July. However, Sessions and other Republicans are asking that the hearing be conducted after the break, citing the need to read through the approximately 3,000 opinions Sotomayor wrote as an appellate court judge (Friedman, CongressDaily, 6/2). Meanwhile, Sotomayor on Wednesday will meet with 10 more senators, including seven Democrats and three Republicans (Koffler, Roll Call, 6/2). Poll Shows Public SupportFifty-four percent of U.S. residents would like to see Sotomayor confirmed as a Supreme Court justice, according to a Gallup poll released Tuesday. The poll shows that 28% of those surveyed opposed the confirmation and 19% had no opinion. The poll was conducted between Friday and Sunday, questioning 1,015 adults (Silva, Los Angeles Times, 6/2).Broadcast CoverageNPR"s "All Things Considered" on Tuesday reported on Sotomayor"s meetings with senators. The segment includes comments from Leahy (Seabrook, "All Things Considered," NPR, 6/3).
Terrence Higgins Trust is using this year"s National Condom Week (18-24 May) as an opportunity to promote safer sex. The aim of the initiative is to raise awareness of the importance of condom use to prevent sexually transmitted infections and unplanned pregnancies.
In future, cartilage, tendon and blood vessel tissue will be produced in the laboratory, with cells being grown on a porous frame, such as non-wovens. A new software program helps to characterize and optimize the non-wovens.
The WHO on Tuesday said it was "getting closer" to declaring the H1N1 (swine) flu outbreak to be a pandemic, as the virus continues to spread to people outside of North America, and in populations "as far apart as Britain, Spain, Japan, Chile and Australia," the AP/Washington Post reports (Jordans, AP/Washington Post, 6/2).
New findings throw light on how the brain heals itself and may change the way we think about treating chronic neurodegenerative diseases like Parkinson"s and Alzheimer"s.
In a development aimed at improving patient outcomes, physicians treating thoracic aortic aneurysms (TAA) will now experience a new level of control while placing endografts during thoracic endovascular repair procedures. With the launch of Cook Medical"s new Z-TRAK PLUS™ Introduction System, physicians are provided with improved maneuverability for controllable device orientation and deployment of the Zenith® TX2™ TAA Endovascular Stent Graft compared to earlier Cook delivery systems.
The Western North Carolina AIDS Project recently launched a media campaign that seeks to raise awareness about the stigma associated with HIV/AIDS and its effect on those living with the virus, as well as the community, the Asheville Citizen-Times reports. The "I Need You to Know" campaign, which will include a set of commercials featuring area residents talking about HIV/AIDS, will serve as a starting point for other prevention efforts (Boyd, Asheville Citizen-Times, 6/3).
More than a decade after Harvard researchers first revealed that life and health insurance companies were major investors in tobacco stocks - prompting calls upon them to divest - the insurance industry has yet to kick the habit, they say.
A promising antimicrobial agent already known to kill bacteria can also kill viruses and stimulate the innate immune system, according to researchers at National Jewish Health. In a paper appearing online June 4 in the Journal of Investigative Dermatology, Michael Howell, PhD, Assistant Professor of Pediatrics, and his colleagues demonstrated that the synthetic compound CSA-13 can kill vaccinia virus in cell cultures and in mice. Additionally, they showed that CSA-13 stimulates cells to produce their own antimicrobial proteins.
Interim results from an ongoing phase 2, randomized, placebo-controlled trial of the investigational drug TMC207 for the treatment of multidrug-resistant tuberculosis (MDR-TB) were published in the New England Journal of Medicine. TMC207 is being developed by Tibotec BVBA. The data show that the addition of TMC207 for eight weeks to a 5-drug background regimen, in patients with multidrug-resistant tuberculosis (MDR-TB), resulted in a significant increase in the proportion of patients achieving a negative sputum culture and a shorter time to sputum culture conversion compared with the background regimen alone.
Children are especially vulnerable in the hospital and they are the population at highest risk of a medication error, according to the American Academy of Pediatrics. Meeting their needs in this environment can be especially challenging. The Joint Commission and Joint Commission Res (JCR) "Pediatric Conference: Safe Care, Quality Care, We Care" will help health care organizations review current pediatric emergency and perioperative services as benchmarks to improve their organizational approaches. JCR is a not-for-profit affiliate of The Joint Commission.
Australia"s regenerative medicine company, Mesoblast Limited (ASX:MSB)(PINK:MBLTY), announced positive three-month interim efficacy results from the first 20 patients enrolled in the Phase 2 heart failure trial of the proprietary allogeneic, or "off-the-shelf", adult stem cell product Revascor(TM).
The United Nations World Food Programme (WFP) announced
Scientists at the Institute for Research in Immunology and Cancer (IRIC) of the Universitçİ de Montrçİal have discovered a key mechanism used by cells to efficiently distribute chromosomes to new cells during cell multiplication. Published in the journal Molecular Cell, the study is the first to demonstrate that this mechanism relies on the polo kinase, an enzyme implicated in several cancers. Inhibiting this mechanism could be key to developing effective therapies to treat cancer.
A national public health campaign in France was associated with a marked
Cancer develops when cells known as cancer stem cells begin to divide in
A University of Toronto study provides the first direct evidence that our mood literally changes the way our visual system filters our perceptual experience suggesting that seeing the world through rose-coloured glasses is more biological reality than metaphor.